An observational study by researchers from Fudan University, published in the Journal of Affective Disorders, tracked 461,586 participants in the UK Biobank database over a median of 13.4 years, all free of mood and stress disorders at enrollment. Over the follow-up period, researchers identified 18,220 new mood disorder cases and 18,547 stress disorder cases.
The main finding shows a J-shaped relationship: the lowest risk for both types of disorders was seen among people drinking two to three cups of coffee a day, while risk was higher both among non-drinkers and heavier consumers. The pattern held whether the coffee was caffeinated, decaffeinated, ground, or instant, and the association was more pronounced in men, potentially due to differences in caffeine metabolism. Caffeine-metabolism genotypes did not meaningfully alter the relationship, and the authors reported no competing interests or specific funding for the study.
Source: Daily Coffee News